Epidermal Growth Factor Receptor

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 ALA-763   TYR-764  6.4 5.4 -5.7 9.3 125.6 142.2 -6.1
 TYR-764   VAL-765  4.8 5.2 -16.4 11.5 71.6 71.4 -13.1
 VAL-765   MET-766  6.5 5.9 -4.5 -7.6 33.3 64.2 11.3
 MET-766   ALA-767  4.8 2.9 8.7 -6.8 81.1 53.8 -10.8
 ALA-767   SER-768  1.4 0.8 -16.0 39.6 105.9 120.9 33.1
 SER-768   VAL-769  4.7 4.3 -37.2 -28.2 56.1 58.6 104.3
 VAL-769   ASP-770  7.0 6.3 9.2 -62.4 100.8 105.4 49.2
 ASP-770   ASN-771  10.1 8.1 125.6 -75.2 166.9 123.1 -89.3
 ASN-771   PRO-772  11.0 10.3 4.6 10.3 141.9 151.0 -27.3
 PRO-772   HIS-773  10.7 11.2 -5.4 -3.3 49.2 42.5 12.7
 HIS-773   VAL-774  9.7 10.0 13.6 -8.4 69.9 71.7 14.1
 VAL-774   CYS-775  7.2 7.1 -2.2 7.9 99.3 95.1 2.6
 CYS-775   ARG-776  3.5 3.4 -12.0 -13.2 165.9 163.7 -67.4
 ARG-776   LEU-777  2.4 3.0 -6.1 1.7 93.6 91.7 3.8
 LEU-777   LEU-778  1.2 2.1 2.2 -0.1 64.3 65.7 -2.5

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 LEU-792   MET-793  5.9 6.2 -10.5 9.7 56.7 56.9 23.2
 MET-793   PRO-794  3.5 4.1 7.9 16.9 166.7 159.7 -73.1
 PRO-794   PHE-795  5.5 5.8 -29.0 -1.1 36.3 40.4 76.1
 PHE-795   GLY-796  3.3 3.7 15.5 -11.7 93.9 81.2 -23.9
 GLY-796   CYS-797  1.1 0.7 19.9 16.7 82.1 86.9 3.0
 CYS-797   LEU-798  3.5 3.1 -15.8 -5.8 45.2 54.3 43.8

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees