DynDom - Protein Domain Motions

Acetyl-Coa Carboxylase 1

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Acetyl-Coa Carboxylase 1
Conformer 1 (PDB)	8xl2 (B)
Conformer 2 (PDB)	8wej (B)
Window Length	7
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	23	8.0	1292 - 1301 1330 - 1361
2	61	11.02	1113 - 1164 1253 - 1289
3	28	5.22	1362 - 1389
4	95	13.51	1466 - 1583
5	20	5.17	1398 - 1403 1452 - 1465
6	73	13.68	1584 - 1656
7	47	11.43	1669 - 1715
8	33	10.38	1727 - 1759

Sequence

`________________________________________________________________________________________________________________________` `8xl2(B) : EKVQAERPDTMLGVVCGALHVADVSLRNSVSNFLHSLERGQVLPAHTLLNTVDVELIYEGVKYVLKVTRQSPNSYVVIMNGSCVEVDVHRLSDGGLLLSYDGSSYTTYMKEEVDRYRITI` `:` `8wej(B) : **********************************************************************************************************************` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `8xl2(B) : GNKTCVFEKEeKLHRVFHYVLDNLVNVMNGYCLPDPFFSSKVKDWVERLMKTLRDPSLPLLELQDIMTSVSGRIPPNVEKSIKKEMAQYASNITSVLCQFPSQQIANILDSHAATLNRKS` `:` `8wej(B) : ********************************************************************************************************************` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `8xl2(B) : EREVFFMNTQSIVQLVQRYRSGIRGHMKAVVMDLLRQYLRVETQFQNGHYDKCVFALREENKSDMNTVLNYIFSHAQVTKKNLLVTMLIDQLCGRDPTLTDELLNILTELTQLSKTTNAK` `:` `8wej(B) : ********************************************************************************************************************` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `8xl2(B) : VALRARQVLIASHLPSYELRHNQVESIFLSAIDMYGHQFCIENLQKLILSETSIFDVLPNFFYHSNQVVRMAALEVYVRRAYIAYELNSVQHRQLKDNTCVVEFQFMLPTSHPqRMGGMV` `:` `8wej(B) : *******************GNWAVNEGLSIFVILVWLGLNVFLFVWYYRVYDIPPKFFYTRKLLGSALALARAPAACLNFNCMLILLPVCRNLLSFLRGSSACCSTRVRRQLDRNL` `________________________________________________________________________________________________________________________` `____________________1289______________________________________________________1361________________________1389__________` `8xl2(B) : SFRTFEDFVRIFDEVMGCePIHILNVAIKTDCDIEDDRLAAMFREFTQQNKATLVDHGIRRL-----TFLVAfPKFFTFRARDKFEEDRIYRHLEPALAFQLELNRMRNFDLTAIPCANH` `:` `8wej(B) : TFHKMVAWMIALHSAIHTIAHLFNVEWCVNARVNNSDPYSVALSELGDRQNESYLNFARKRIKNPEGGLYLAVTLLAGITGVVITLCLILIITSSTKTIRRSYFEVFWYTHHLFVIFFIG` `_____________________122_______________________________________________________180_________________________208__________` `______________________________________________________________1465______________________________________________________` `8xl2(B) : KMHLYLGAAKVEVGTEVTDYRFFVRAIIRHSDLVTKEASFEYLQNEGERLLLEAMDELEVAFNNTNVRTDCNH-IFLNFVPTVIMDPS--KIEESVRSMVMRYGSRLWKLRVLQAELKIN` `:` `8wej(B) : LAIHGAERIVRGQTAESLAVHNITVCEQKISEWGKIKECPIPQFAGNPPMTWKWIVGPMFLYLCERL--VRFWRSQQK-VVITKVVTHPFKTIELQMK---------KKGFKMEVGQYIF` `_______________________________________________________________284______________________________________________________` `__________________________________________________________________1583__________________________________________________` `8xl2(B) : IRaIPIRLFLTNESGYYLDI----SLYKEVTDSRTAQI-MFQAYGDKQGPLHGM-LIN---TPYVTKDLLQSKRFQAQSLGTTYIYDIPEMFRQSLIKLWESMSTQAFLPSPPLPSDMLT` `:` `8wej(B) : VKCPKVSKLEWHPFTLTSAPEEDFFSI---HIRIVGDWTEG--LFNACGCDKQEFQDAWKLPKIAVDGPFGTASEDVFSYEVVMLVGAGIGVTPFASILKSVWYKYCNNATNLKLKKIYF` `___________________________________________________________________391__________________________________________________` `___________________1656_______________________________________________________1715______________________________________` `8xl2(B) : YTELVLDDQGQLVHMNRLPGGNEIGMVAWKMTFKSPEYPEGRDIIVIGNDITYRIGSFGPQEDLLFLRASELARAEGIPRIYVSANSGARIGLAEEIRHMFHVAWVDPEDPYKGYRYLYL` `:` `8wej(B) : YWLCRDTHAFEWFADLLQLLESQMQERNNAGFLSYNIYLTGWDESQANHFAVHHDEEKDVITGLKQKTLYGRPNWDNEFKTIASQHPNTRIGVFLCGPEALAETLSKQSISNSESGPRGV` `____________________464________________________________________________________523______________________________________` `________________________________________________________________________________________________________________________` `8xl2(B) : TPQDYKRVSALNSVHCEHVEDEGESRYKITDIIGKEEGIGPENLRGSGMIAGESSLAYNEIITIS-LVTCRAIGIGAYLVRLGQRTIQVENSHLILTGAGALNKVLGREVYTSNNQLGGI` `:` `8wej(B) : HFIFNKENF***********************************************************************************************************` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `8xl2(B) : QIMHNNGVTHCTVCDDFEGVFTVLHWLSYMPKSVHSSVPLLNSKDPIDRIIEFVPTKTPYDPRWMLAGRPHPTQKGQWLSGFFDYGSFSEIMQPWAQTVVVGRARLGGIPVGVVAVETRT` `:` `8wej(B) : ********************************************************************************************************************` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `8xl2(B) : VELSIPADPANLDSEAKIIQQAGQVWFPDSAFKTYQAIKDFNREGLPLMVFANWRGFSGGMKDMYDQVLKFGAYIVDGLRECCQPVLVYIPPQAELRGGSWVVIDSSINPRHMEMYADRE` `:` `8wej(B) : ********************************************************************************************************************` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `8xl2(B) : SRGSVLEPEGTVEIKFRRKDLVKTMRRVDPVYIHLAERLGTPELSTAERKELENKLKEREEFLIPIYHQVAVQFADLHDTPGRMQEKGVISDILDWKTSRTFFYWRLRRLLLEDLVKKKI` `:` `8wej(B) : ********************************************************************************************************************` `________________________________________________________________________________________________________________________` `_________________________________________________________________________________________________________` `8xl2(B) : HNANPELTDGQIQAMLRRWFVEVEGTVKAYVWDNNKDLAEWLEKQLTEEDGVHSVIEENIKCISRDYVLKQIRSLVQANPEVAMDSIIHMTQHISPTQRAEVIRI` `:` `8wej(B) : *******************************************************************************************************` `_________________________________________________________________________________________________________`

Morph

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Domain Pairs

Fixed Domain	Moving Domain	Rotation Angle	Translation (A)	Closure	Bending Residues
1	2	153.7	-12.1	56.0	1289 - 1292	Bending Region Analysis
1	3	116.0	0.3	1.7	1361 - 1365	Bending Region Analysis
3	5	136.7	-16.1	94.9	1389 - 1398	Bending Region Analysis
4	5	162.7	6.6	98.7	1465 - 1466	Bending Region Analysis
4	6	114.5	-7.9	91.5	1583 - 1584	Bending Region Analysis
7	6	153.2	-1.9	82.6	1656 - 1670	Bending Region Analysis
7	8	61.5	-10.5	98.6	1715 - 1727	Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 4 ———› Residue 5

Conformer 2 Contact:
Residue 5 ———› Residue 4

Movement classification: Hinge

Conformer 1 Contact:
Residue 4 ———› Residue 6

Conformer 2 Contact:
Residue 6 ———› Residue 4

Movement classification: Hinge

Conformer 1 Contact:
Residue 7 ———› Residue 6

Conformer 2 Contact:
Residue 6 ———› Residue 7

Movement classification: Hinge

Conformer 1 Contact:
Residue 7 ———› Residue 8

Conformer 2 Contact:
Residue 8 ———› Residue 7

Movement classification:

No Contacts

Conformer 1 Contact:
Residue 3 ———› Residue 5

Conformer 2 Contact:
Residue 5 ———› Residue 3

Movement classification: Hinge

PyMOL Script

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