DynDom - Protein Domain Motions

Alcohol Dehydrogenase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Alcohol Dehydrogenase
Conformer 1 (PDB)	4rqu (B)
Conformer 2 (PDB)	4rqt (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	227	0.43	7 - 105 108 - 175 179 - 179 226 - 227 230 - 231 275 - 278 296 - 301 327 - 337 344 - 377
2	144	0.49	106 - 107 176 - 178 180 - 225 228 - 229 232 - 274 279 - 295 302 - 326 338 - 343

Sequence

`_____________________________________________________________________________________________100________________________` `4rqu(B) : SQIIRCKAAVAWEAGKPLVIEEVEVAPPQKHEVRIKILFTSLCHTDVYFWEAKGQTPLFPRIFGHEAGGIVESVGEGVTDLQPGDHVLPIFTGECGECRHCHSEESNMCDLLRINTERGG` `:` `4rqt(A) : SQIIRCKAAVAWEAGKPLVIEEVEVAPPQKHEVRIKILFTSLCHTDVYFWEAKGQTPLFPRIFGHEAGGIVESVGEGVTDLQPGDHVLPIFTGECGECRHCHSEESNMCDLLRINTERGG` `_____________________________________________________________________________________________100________________________` `_______________________________________________174_178____________________________________________225___________________` `4rqu(B) : MIHDGESRFSINGKPIYHFLGTSTFSEYTVVHSGQVAKINPDAPLDKVCIVSCGLSTGLGATLNVAKPKKGQSVAIFGLGAVGLGAAEGARIAGASRIIGVDFNSKRFDQAKEFGVTECV` `:` `4rqt(A) : MIHDGESRFSINGKPIYHFLGTSTFSEYTVVHSGQVAKINPDAPLDKVCIVSCGLSTGLGATLNVAKPKKGQSVAIFGLGAVGLGAAEGARIAGASRIIGVDFNSKRFDQAKEFGVTECV` `_______________________________________________174_178____________________________________________225___________________` `___________________________274_278______________295____________________________326________337___343_____________________` `4rqu(B) : NPKDHDKPIQQVIAEMTDGGVDRSVECTGSVQAMIQAFECVHDGWGVAVLVGVPSKDDAFKTHPMNFLNERTLKGTFFGNYKPKTDIPGVVEKYMNKELELEKFITHTVPFSEINKAFDY` `:` `4rqt(A) : NPKDHDKPIQQVIAEMTDGGVDRSVECTGSVQAMIQAFECVHDGWGVAVLVGVPSKDDAFKTHPMNFLNERTLKGTFFGNYKPKTDIPGVVEKYMNKELELEKFITHTVPFSEINKAFDY` `___________________________274_278______________295____________________________326________337___343_____________________` `_______________` `4rqu(B) : MLKGESIRCIITMGA` `:` `4rqt(A) : MLKGESIRCIITMGA` `_______________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	4.1
Translation (A)	0.1
Closure (%)	71.5
Bending Residues ( green )	100 - 108 174 - 176 178 - 182 225 - 232 274 - 275 278 - 279 295 - 302 326 - 327 337 - 340 343 - 344
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

PyMOL Script

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