Angiotensin I Converting Enzyme 2

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Angiotensin I Converting Enzyme 2
  Conformer 1
(PDB) 		1r4l (A)
  Conformer 2
(PDB) 		1r42 (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 329 0.76   97 - 97   101 - 290   395 - 398   431 - 431   435 - 521   566 - 578   581 - 613
2 205 0.81   21 - 96   98 - 100   293 - 390   402 - 402   407 - 421   548 - 548   550 - 560
3 42 1.05   399 - 401   403 - 406   428 - 430   432 - 434   522 - 547   549 - 549   579 - 580

Sequence


           __________________________________________________________________________94____________________________________________ 
 1r4l(A) : STIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNP 
         :                                                                                                                          
 1r42(A) : STIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNP 
           __________________________________________________________________________94____________________________________________ 

           ________________________________________________________________________________________________________________________ 
 1r4l(A) : QECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPSYISP 
         :                                                                                                                          
 1r42(A) : QECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPSYISP 
           ________________________________________________________________________________________________________________________ 

           ___________________________288__________________________________________________________________________________________ 
 1r4l(A) : IGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQKAVCHPTAWDLGKGDFRILMCTKVTMDDFLTAHHEMGH 
         :                                                                                                                          
 1r42(A) : IGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQKAVCHPTAWDLGKGDFRILMCTKVTMDDFLTAHHEMGH 
           ___________________________288__________________________________________________________________________________________ 

           _________390__395___401__406__________419______428______________________________________________________________________ 
 1r4l(A) : IQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYC 
         :                                                                                                                          
 1r42(A) : IQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYC 
           _________390__395___401__406__________419______428______________________________________________________________________ 

           ____________________521_____________________545____________560_______________578_____________________________________    
 1r4l(A) : DPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKDQNKNSFVGWSTDWSPYAD    
         :                                                                                                                          
 1r42(A) : DPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKDQNKNSFVGWSTDWSPYAD    
           ____________________521_____________________545____________560_______________578_____________________________________    

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Fixed Domain Moving Domain Rotation Angle Translation   (A) Closure Bending Residues  
1 2 21.9 -1.1 73.6   94 - 114   288 - 293   390 - 398   560 - 566 Bending Region Analysis
1 3 16.6 0.0 83.4   395 - 399   428 - 435   521 - 522   578 - 581 Bending Region Analysis
2 3 8.2 -0.1 16.4   401 - 403   406 - 407   419 - 430   545 - 550 Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 2 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 2

Movement classification: Hinge

PyMOL Script

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