Calmodulin-Domain Protein Kinase 1

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Calmodulin-Domain Protein Kinase 1
  Conformer 1
(PDB) 		3i79 (A)
  Conformer 2
(PDB) 		3hx4 (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 81 5.47   340 - 353   435 - 501
2 259 5.51   47 - 312
3 22 3.26   355 - 373   432 - 434
4 49 3.84   375 - 431

Sequence


           ________________________________________________________________________________________________________________________ 
 3i79(A) : ***************AIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEV 
         :                                                                                                                          
 3hx4(A) : DHLHATPGMFVQHSTAIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISK-------dKESLLREVQLLKQLDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEV 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 3i79(A) : DAARIIRQVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTF 
         :                                                                                                                          
 3hx4(A) : DAARIIRQVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTF 
           ________________________________________________________________________________________________________________________ 

           ________________________________________312__________________________________349___________________371__________________ 
 3i79(A) : ELPQWKKVSESAKDLIRKMLTYVPSMRISARDALDHEWIQTYTKEQISVDVPSLDNAILNIRQFQGTQKLAQAALLYMGSKLTSQDETKELTAIFHKMDKNGDGQLDRAELIEGYKELMR 
         :                                                                                                                          
 3hx4(A) : ELPQWKKVSESAKDLIRKMLTYVPSMRISARDALDHEWIQTYTKEQISVDVPSLDNAILNIRQFQGTQKLAQAALLYMGSKLTSQDETKELTAIFHKMDKNGDGQLDRAELIEGYKELMR 
           ________________________________________312__________________________________349___________________371__________________ 

           __________________________________________434_________________________________________________________________________   
 3i79(A) : MKGQDASMLDASAVEHEVDQVLDAVDF--------sEFVTVAMDRKTLLSRERLERAFRMFDSDNSGKISSTELATIFGVSDVDSETWKSVLSEVDKNNDGEVDFDEFQQMLLKLCGN   
         :                                                                                                                          
 3hx4(A) : MKGQDASMLDASAVEHEVDQVLDAVDFDKNGYIEYSEFVTVAMDRKTLLSRERLERAFRMFDSDNSGKISSTELATIFGVSDVDSETWKSVLSEVDKNNDGEVDFDEFQQMLLK****   
           __________________________________________434_________________________________________________________________________   

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Domain Pairs

Fixed Domain Moving Domain Rotation Angle Translation   (A) Closure Bending Residues  
1 2 162.0 -0.8 84.6   312 - 340 Bending Region Analysis
1 3 168.2 -1.2 32.4   349 - 355   434 - 437 Bending Region Analysis
4 3 49.8 0.4 74.1   371 - 375   431 - 432 Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification:

No Contacts

Conformer 1 Contact:
Residue 4 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 4

Movement classification: Hinge

PyMOL Script

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