E3 Ubiquitin-Protein Ligase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name E3 Ubiquitin-Protein Ligase
  Conformer 1
(PDB) 		2y1m (A)
  Conformer 2
(PDB) 		2y1n (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 313 1.69   54 - 373
2 56 1.53   374 - 429

Sequence


           ________________________________________________________________________________________________________________________ 
 2y1m(A) : PPGTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLPDTYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKTKQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELK 
         :                                                                                                                          
 2y1n(A) : *****DKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLPDTYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKTKQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELK 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 2y1m(A) : GIFPSGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIH 
         :                                                                                                                          
 2y1n(A) : GIFPSGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIH 
           ________________________________________________________________________________________________________________________ 

           ______________________________________________________________________________372_______________________________________ 
 2y1m(A) : KPGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQALIDGFREGFYLFPDGRNQNPDLTGLCdHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQES 
         :                                                                                                                          
 2y1n(A) : KPGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQALIDGFREGFYLFPDGRNQNPDLTGLCE--kVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQES 
           ______________________________________________________________________________372_______________________________________ 

           ________________________                                                                                                 
 2y1m(A) : EGQGCPFCRCEIKGTEPIVVDPFD                                                                                                 
         :                                                                                                                          
 2y1n(A) : EGQGCPFCRCEIKGTEPIVVDPFD                                                                                                 
           ________________________                                                                                                 

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		85.1
Translation
(A) 		1.1
Closure
(%) 		41.0
Bending Residues
( green ) 		  372 - 375
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

Download and extract PyMOL PML script file Download