Fanconi-Associated Nuclease 1

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Fanconi-Associated Nuclease 1
  Conformer 1
(PDB) 		4rea (B)
  Conformer 2
(PDB) 		4reb (A)
  Window Length 13
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 184 0.57   550 - 552   822 - 1002
2 68 0.62   407 - 462   538 - 549
3 175 0.79   553 - 745   766 - 766
4 20 0.44   746 - 765
5 28 0.46   379 - 406
6 30 0.86   463 - 469   494 - 537

Sequence


           ________________________________405______________________________________________________462____________________________ 
 4rea(B) : EFPYYLRSFLVVLKTVLENEDDMLLFDEQEKGIVTKFYQLSATGQKLYVRLFQRKLSWIKMTKLEYEEIALDLTPVIEELTNAGFLQTESELQELSEVLELLSAPELKSLAKTFHLVNPN 
         :                                                                                                                          
 4reb(A) : EFPYYLRSFLVVLKTVLENEDDMLLFDEQEKGIVTKFYQLSATGQKLYVRLFQRKLSWIKMTKLEYEEIALDLTPVIEELTNAGFLQTESELQELSEVLELLSAPELKSLAKTFHLVNPN 
           ________________________________405______________________________________________________462____________________________ 

           _________________________________537_________549________________________________________________________________________ 
 4rea(B) : GQKQQLVDAFLKLAKQgIGAVILKRAKALAGQSVRICKGPRAVFSRILLLFSLTDSMEDElLVNLGRMEFPSYTINRKTHIFQDRDDLIRYAAATHMLSDISSAMANGNWEEAKELAQCA 
         :                                                                                                                          
 4reb(A) : GQKQQLVDAFLKLA----------rAKALAGQSVRICKGPRAVFSRILLLFSLT------lLVNLGRMEFPSYTINRKTHIFQDRDDLIRYAAATHMLSDISSAMANGNWEEAKELAQCA 
           _________________________________537_________549________________________________________________________________________ 

           ___________________________________________________________________________________________________________744__________ 
 4rea(B) : KRDWNRLKNHPSLRCHEDLPLFLRCFTVGWIYTRILSRFVEILQRLHMYEEAVRELESLLSQRIYCPDSRGRWWDRLALNLHQHLKRLEPTIKCITEGLADPEVRTGHRLSLYQRAVRLR 
         :                                                                                                                          
 4reb(A) : KRDWNRLKNHPSLRCHEDLPLFLRCFTVGWIYTRILSRFVEILQRLHMYEEAVRELESLLSQRIYCPDSRGRWWDRLALNLHQHLKRLEPTIKCITEGLADPEVRTGHRLSLYQRAVRLR 
           ___________________________________________________________________________________________________________744__________ 

           _________766____________________________________________________________________________________________________________ 
 4rea(B) : ESPSCKKFKHLFQQLPEMAVQDVKHVTITlCSVEELALAHYRRSGFDQGIHGEGSTFSTLYGLLLWDIIFMDGIPDVFRNACQAFPLDLCTDSFFTSRRPALEARLQLIHDAPEESLRAW 
         :                                                                                                                          
 4reb(A) : ESPSCKKFKHLFQQLPEM----vKHVTIT-cSVEELALAHYRRSGFDQGIHGEGSTFSTLYGLLLWDIIFMDGIPDVFRNACQAFPLDLCTDSFFTSRRPALEARLQLIHDAPEESLRAW 
           _________766____________________________________________________________________________________________________________ 

           ____________________________________________________________________________________________________________             
 4rea(B) : VAATWHEQEGRVASLVSWDRFTSLQQAQDLVSCLGGPVLSGVCRHLAADFRHCRGGLPALVVWNSQSRHFKLVEVKGPNDRLSHKQMIWLAELQKLGAEVEVCHVVAV             
         :                                                                                                                          
 4reb(A) : VAATWHEQEGRVASLVSWDRFTSLQQAQDLVSCLGGPVLSGVCRHLAADFRHCRGGLPALVVWNSQSRHFKLVEVKGPNDRLSHKQMIWLAELQKLGAEVEVCHVVA*             
           ____________________________________________________________________________________________________________             

Morph
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Domain Pairs

Fixed Domain Moving Domain Rotation Angle Translation   (A) Closure Bending Residues  
1 2 4.1 0.0 39.5   549 - 550 Bending Region Analysis
1 3 5.5 -0.4 95.7   552 - 553   766 - 822 Bending Region Analysis
1 4 9.3 1.1 0.3   765 - 822 Bending Region Analysis
2 5 7.1 -0.3 78.8   405 - 408 Bending Region Analysis
2 6 10.5 0.4 47.7   462 - 463   537 - 538 Bending Region Analysis
3 4 7.0 0.3 96.7   744 - 746   765 - 766 Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 1 ———› Residue 4

Conformer 2 Contact:
Residue 4 ———› Residue 1

Movement classification:

No Contacts

Conformer 1 Contact:
Residue 2 ———› Residue 5

Conformer 2 Contact:
Residue 5 ———› Residue 2

Movement classification: Hinge

Conformer 1 Contact:
Residue 2 ———› Residue 6

Conformer 2 Contact:
Residue 6 ———› Residue 2

Movement classification: Hinge

Conformer 1 Contact:
Residue 3 ———› Residue 4

Conformer 2 Contact:
Residue 4 ———› Residue 3

Movement classification: Hinge

PyMOL Script

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