DynDom - Protein Domain Motions

Glutamate Receptor 2

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Glutamate Receptor 2
Conformer 1 (PDB)	7rz4 (A)
Conformer 2 (PDB)	7rz6 (A)
Window Length	11
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	101	0.77	502 - 508 635 - 725 771 - 773
2	129	0.68	394 - 449 461 - 496 732 - 768
3	286	0.92	516 - 634 786 - 805 847 - 1025
4	390	0.82	15 - 393 450 - 460

Sequence

`________________________________________________________________________________________________________________________` `7rz4(A) : NSIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTPHIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGTHPFVIQMRPDLKGALLSLIEYYQ` `:` `7rz6(A) : NSIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTPHIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGTHPFVIQMRPDLKGALLSLIEYYQ` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `7rz4(A) : WDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDKKDETYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFGGAEVSGFQIVD` `:` `7rz6(A) : WDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDKKDETYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFGGAEVSGFQIVD` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `7rz4(A) : YDDSLVSKFIERWSTLEEKEYPGAHTATIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPR` `:` `7rz6(A) : YDDSLVSKFIERWSTLEEKEYPGAHTATIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPR` `________________________________________________________________________________________________________________________` `_________________389__________________________________________________442___________456_________________________________` `7rz4(A) : KIGYWSEVDKMVLTEDDTSGLEQKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVI` `:` `7rz6(A) : KIGYWSEVDKMVLTEDDTSGLEQKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVI` `_________________389__________________________________________________442___________456_________________________________` `___495__________508_____________________________________________________________________________________________________` `7rz4(A) : DFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYsTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTV` `:` `7rz6(A) : DFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSP---nEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTV` `___495__________508_____________________________________________________________________________________________________` `_____634________________________________________________________________________________________725_____________________` `7rz4(A) : ERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLGTPV` `:` `7rz6(A) : ERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLGTPV` `_____634________________________________________________________________________________________725_____________________` `___________________768__773_____________________________________________________________________________________________` `7rz4(A) : NLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAaCGRKALTLLSSVFAVCGLGLLGIAVSTDYWLYLEEGIILPQNQ` `:` `7rz6(A) : NLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRa---CGRKALTLLSSVFAVCGLGLLGIAVSTDYWLYLEEGIILPQNQ` `___________________768__773_____________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `7rz4(A) : STEVKMSLHSGLWRVCFLAGEERGRCFTIEYVMeSTVNVLKMIRSATPFPLVSLFFMFIGFILSNIGHIRPHRTILAFVSGIFFILSGLSLVVGLVLYISSINDEMLNRTKDAETYFNYK` `:` `7rz6(A) : STEVKMSLHSGLWRVCFLAGEERGRCFTIEYVMeSTVNVLKMIRSATPFPLVSLFFMFIGFILSNIGHI----tILAFVSGIFFILSGLSLVVGLVLYISSINDEMLNRTKDAETYFNYK` `________________________________________________________________________________________________________________________` `_________________________________` `7rz4(A) : YGWSFAFAAISFLLTESAGVMSVYLFMKRYTAE` `:` `7rz6(A) : YGWSFAFAAISFLLTESAGVMSVYLFMKRYTAE` `_________________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Fixed Domain	Moving Domain	Rotation Angle	Translation (A)	Closure	Bending Residues
1	2	27.2	0.3	100.0	495 - 502 725 - 732 768 - 771	Bending Region Analysis
1	3	12.0	-1.0	61.0	508 - 516 634 - 635 773 - 790	Bending Region Analysis
4	2	11.2	0.5	100.0	389 - 394 442 - 450 456 - 462	Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification:

No Contacts

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification:

No Contacts

Conformer 1 Contact:
Residue 4 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 4

Movement classification: Hinge

PyMOL Script

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