DynDom - Protein Domain Motions

Importin Beta-1 Subunit

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Importin Beta-1 Subunit
Conformer 1 (PDB)	2bku (D)
Conformer 2 (PDB)	2bku (B)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	98	0.36	189 - 189 196 - 273 299 - 315 324 - 325
2	185	0.34	3 - 188 193 - 195
3	326	0.37	274 - 298 316 - 323 326 - 597 602 - 629
4	67	0.4	598 - 601 630 - 668 673 - 673 677 - 699
5	166	0.3	669 - 672 674 - 676 701 - 859

Sequence

`________________________________________________________________________________________________________________________` `2bku(D) : MSTAEFAQLLENSILSPDQNIRLTSETQLKKLSNDNFLQFAGLSSQVLIDENTKLEGRILAALTLKNELVSKDSVKTQQFAQRWITQVSPEAKNQIKTNALTALVSIEPRIANAAAQLIA` `:` `2bku(B) : MSTAEFAQLLENSILSPDQNIRLTSETQLKKLSNDNFLQFAGLSSQVLIDENTKLEGRILAALTLKNELVSKDSVKTQQFAQRWITQVSPEAKNQIKTNALTALVSIEPRIANAAAQLIA` `________________________________________________________________________________________________________________________` `________________________________________________________________187_____________________________________________________` `2bku(D) : AIADIELPHGAWPELMKIMVDNTGAEQPENVKRASLLALGYMCESADPQSQALVSSSNNILIAIVQGAQSTETSKAVRLAALNALADSLIFIKNNMEREGERNYLMQVVCEATQAEDIEV` `:` `2bku(B) : AIADIELPHGAWPELMKIMVDNTGAEQPENVKRASLLALGYMCESAD----aLVSSSNNILIAIVQGAQSTETSKAVRLAALNALADSLIFIKNNMEREGERNYLMQVVCEATQAEDIEV` `________________________________________________________________187_____________________________________________________` `_____________________________272_______________________298______________315_____323_____________________________________` `2bku(D) : QAAAFGCLCKIMSKYYTFMKPYMEQALYALTIATMKSPNDKVASMTVEFWSTICEEEIDIAYELAQFPQSPLQSYNFALSSIKDVVPNLLNLLTRQNEDPEDDDWNVSMSAGACLQLFAQ` `:` `2bku(B) : QAAAFGCLCKIMSKYYTFMKPYMEQALYALTIATMKSPNDKVASMTVEFWSTICEEEIDIAYELAQFPQSPLQSYNFALSSIKDVVPNLLNLLTRQNEDPEDDDWNVSMSAGACLQLFAQ` `_____________________________272_______________________298______________315_____323_____________________________________` `________________________________________________________________________________________________________________________` `2bku(D) : NCGNHILEPVLEFVEQNITADNWRNREAAVMAFGSIMDGPDKVQRTYYVHQALPSILNLMNDQSLQVKETTAWCIGRIADSVAESIDPQQHLPGVVQACLIGLQDHPKVATNCSWTIINL` `:` `2bku(B) : NCGNHILEPVLEFVEQNITADNWRNREAAVMAFGSIMDGPDKVQRTYYVHQALPSILNLMNDQSLQVKETTAWCIGRIADSVAESIDPQQHLPGVVQACLIGLQDHPKVATNCSWTIINL` `________________________________________________________________________________________________________________________` `__________________________________________________________________________________________________________________597_60` `2bku(D) : VEQLAEATPSPIYNFYPALVDGLIGAANRIDNEFNARASAFSALTTMVEYATDTVAETSASISTFVMDKLGQTMSV-------eDAQSLQELQSNILTVLAAVIRKSPSSVEPVADMLMG` `:` `2bku(B) : VEQLAEATPSPIYNFYPALVDGLIGAANRIDNEFNARASAFSALTTMVEYATDTVAETSASISTFVMDKLGQTMSVDENQLTLEDAQSLQELQSNILTVLAAVIRKSPSSVEPVADMLMG` `__________________________________________________________________________________________________________________597_60` `1_________________________629____________________________________668____________________________699_____________________` `2bku(D) : LFFRLLEKKDSAFIEDDVFYAISALAASLGKGFEKYLETFSPYLLKALNQVDSPVSITAVGFIADISNSLEEDFRRYSDAMMNVLAQMISNPNARRELKPAVLSVFGDIASNIGADFIPY` `:` `2bku(B) : LFFRLLEKKDSAFIEDDVFYAISALAASLGKGFEKYLETFSPYLLKALNQVDSPVSITAVGFIADISNSLEEDFRRYSDAMMNVLAQMISNPNARRELKPAVLSVFGDIASNIGADFIPY` `1_________________________629____________________________________668____________________________699_____________________` `________________________________________________________________________________________________________________________` `2bku(D) : LNDIMALCVAAQNTKPENGTLEALDYQIKVLEAVLDAYVGIVAGLHDKPEALFPYVGTIFQFIAQVAEDPQLYSEDATSRAAVGLIGDIAAMFPDGSIKQFYGQDWVIDYIKRTRSGQLF` `:` `2bku(B) : LNDIMALCVAAQNTKPENGTLEALDYQIKVLEAVLDAYVGIVAGLHDKPEALFPYVGTIFQFIAQVAEDPQLYSEDATSRAAVGLIGDIAAMFPDGSIKQFYGQDWVIDYIKRTRSGQLF` `________________________________________________________________________________________________________________________` `_____________________` `2bku(D) : SQATKDTARWAREQQKRQLSL` `:` `2bku(B) : SQATKDTARWAREQQKRQLSL` `_____________________`

Morph

Morph animation in progress.
Status: Initialising

This morph was created using the MorphIt_Pro protein morphing technique.
For more advanced options, right click on the model.

play backwards

pause

play forwards

Domain Pairs

Fixed Domain	Moving Domain	Rotation Angle	Translation (A)	Closure	Bending Residues
1	2	4.5	0.2	99.9	187 - 196	Bending Region Analysis
1	3	3.9	0.1	85.7	272 - 274 298 - 299 315 - 316 323 - 326	Bending Region Analysis
4	3	3.9	-0.1	5.4	597 - 598 601 - 602 629 - 630	Bending Region Analysis
4	5	6.0	0.0	77.3	668 - 669 671 - 677 699 - 703	Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 4 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 4

Movement classification: Hinge

Conformer 1 Contact:
Residue 4 ———› Residue 5

Conformer 2 Contact:
Residue 5 ———› Residue 4

Movement classification: Hinge

PyMOL Script

Download and extract PyMOL PML script file

Download