DynDom - Protein Domain Motions

Macrophage Mannose Receptor 1

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Macrophage Mannose Receptor 1
Conformer 1 (PDB)	5xts (A)
Conformer 2 (PDB)	5xtw (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	84	0.58	154 - 169 172 - 214 219 - 223 231 - 238 246 - 253 335 - 337 340 - 340
2	131	0.29	25 - 153 170 - 171
3	224	0.47	215 - 218 224 - 230 239 - 245 254 - 334 338 - 339 341 - 487

Sequence

`________________________________________________________________________________________________________________________` `5xts(A) : TRQFLIYNEDHKRCVDAVSPSAVQTAACNQDAESQKFRWVSESQIMSVAFKLCLGVPSKTDWVAITLYACDSKSEFQKWECKNDTLLGIKGEDLFFNYGNRQEKNIMLYKGSGLWSRWKI` `:` `5xtw(A) : RQFLIYNEDHKRCVDAVSPSAVQTAACNQDAESQKFRWVSESQIMSVAFKLCLGVPSKTDWVAITLYACDSKSEFQKWECKNDTLLGIKGEDLFFNYGNRQEKNIMLYKGSGLWSRWKI` `________________________________________________________________________________________________________________________` `________152______________169__________________________________________214______223____230_____238____245_____253________` `5xts(A) : YGTTDNLCSRGYEAMYTLLGNANGATCAFPFKFENKWYADCTSAGRSDGWLWCGTTTDYDTDKLFGYCPLKFEGSESLWNKDPLTSVSYQINSKSALTWHQARKSCQQQNAELLSITEIH` `:` `5xtw(A) : YGTTDNLCSRGYEAMYTLLGNANGATCAFPFKFENKWYADCTSAGRSDGWLWCGTTTDYDTDKLFGYCPLKFEGSESLWNKDPLTSVSYQINSKSALTWHQARKSCQQQNAELLSITEIH` `________152______________169__________________________________________214______223____230_____238____245_____253________` `______________________________________________________________________334_______________________________________________` `5xts(A) : EQTYLTGLTSSLTSGLWIGLNSLSFNSGWQWSDRSPFRYLNWLPGSPSAEPGKSCVSLNPGKNAKWENLECVQKLGYICKKiPSESDVPTHCPSQWWPYAGHCYKIHRDEKKIQRDALTT` `:` `5xtw(A) : EQTYLTGLTSSLTSGLWIGLNSLSFNSGWQWSDRSPFRYLNWLPGSPSAEPGKSCVSLNPGKNAKWENLECVQKLGYICKK---------------wPYAGHCYKIHRDEKKIQRDALTT` `______________________________________________________________________334_______________________________________________` `____________________________________________________________________________________________________` `5xts(A) : CRKEGGDLTSIHTIEELDFIISQLGYEPNDELWIGLNDIKIQMYFEWSDGTPVTFTKWLRGEPSHENNRQEDCVVMKGKDGYWADRGCEWPLGYICKMKS` `:` `5xtw(A) : CRKEGGDLTSIHTIEELDFIISQLGYEPNDELWIGLNDIKIQMYFEWSDGTPVTFTKWLRGEPSHENNRQEDCVVMKGKDGYWADRGCEWPLGYICKMK` `____________________________________________________________________________________________________`

Morph

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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	10.5
Translation (A)	-0.1
Closure (%)	8.5
Bending Residues ( green )	152 - 155 169 - 172
Bending Region Analysis

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( yellow )	3
Rotation Angle (deg)	6.5
Translation (A)	-0.1
Closure (%)	74.2
Bending Residues ( green )	214 - 219 223 - 224 230 - 231 238 - 239 245 - 246 253 - 254 334 - 335 337 - 341
Bending Region Analysis