DynDom - Protein Domain Motions

Macrophage Mannose Receptor 1

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Macrophage Mannose Receptor 1
Conformer 1 (PDB)	5xts (A)
Conformer 2 (PDB)	5xtw (C)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	90	0.6	154 - 170 172 - 212 219 - 221 228 - 228 232 - 241 245 - 252 265 - 269 314 - 316 336 - 337
2	131	0.31	24 - 153 171 - 171
3	216	0.49	213 - 218 222 - 227 229 - 231 242 - 244 253 - 264 270 - 313 317 - 335 338 - 487

Sequence

`________________________________________________________________________________________________________________________` `5xts(A) : TRQFLIYNEDHKRCVDAVSPSAVQTAACNQDAESQKFRWVSESQIMSVAFKLCLGVPSKTDWVAITLYACDSKSEFQKWECKNDTLLGIKGEDLFFNYGNRQEKNIMLYKGSGLWSRWKI` `:` `5xtw(C) : TRQFLIYNEDHKRCVDAVSPSAVQTAACNQDAESQKFRWVSESQIMSVAFKLCLGVPSKTDWVAITLYACDSKSEFQKWECKNDTLLGIKGEDLFFNYGNRQEKNIMLYKGSGLWSRWKI` `________________________________________________________________________________________________________________________` `________152_______________170_______________________________________212___218______227_231_______241________252_________` `5xts(A) : YGTTDNLCSRGYEAMYTLLGNANGATCAFPFKFENKWYADCTSAGRSDGWLWCGTTTDYDTDKLFGYCPLKFEGSESLWNKDPLTSVSYQINSKSALTWHQARKSCQQQNAELLSITEIH` `:` `5xtw(C) : YGTTDNLCSRGYEAMYTLLGNANGATCAFPFKFENKWYADCTSAGRSDGWLWCGTTTDYDTDKLFGYCPLKFEGSESLWNKDPLTSVSYQINSKSALTWHQARKSCQQQNAELLSITEIH` `________152_______________170_______________________________________212___218______227_231_______241________252_________` `264__269_________________________________________313___________________335______________________________________________` `5xts(A) : EQTYLTGLTSSLTSGLWIGLNSLSFNSGWQWSDRSPFRYLNWLPGSPSAEPGKSCVSLNPGKNAKWENLECVQKLGYICKKiPSESDVPTHCPSQWWPYAGHCYKIHRDEKKIQRDALTT` `:` `5xtw(C) : EQTYLTGLTSSLTSGLWIGLNSLSFNSGWQWSDRSPFRYLNWLPGSPSAEPGKSCVSLNPGKNAKWENLECVQKLGYICKK---------------wPYAGHCYKIHRDEKKIQRDALTT` `264__269_________________________________________313___________________335______________________________________________` `____________________________________________________________________________________________________` `5xts(A) : CRKEGGDLTSIHTIEELDFIISQLGYEPNDELWIGLNDIKIQMYFEWSDGTPVTFTKWLRGEPSHENNRQEDCVVMKGKDGYWADRGCEWPLGYICKMKS` `:` `5xtw(C) : CRKEGGDLTSIHTIEELDFIISQLGYEPNDELWIGLNDIKIQMYFEWSDGTPVTFTKWLRGEPSHEN---eDCVVMKGKDGYWADRGCEWPLGYICKMK*` `____________________________________________________________________________________________________`

Morph

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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	10.6
Translation (A)	0.2
Closure (%)	27.1
Bending Residues ( green )	152 - 155 170 - 172
Bending Region Analysis

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( yellow )	3
Rotation Angle (deg)	5.8
Translation (A)	0.0
Closure (%)	60.3
Bending Residues ( green )	212 - 213 218 - 219 221 - 223 227 - 229 231 - 232 241 - 242 244 - 245 252 - 253 264 - 265 269 - 270 313 - 314 316 - 317 335 - 338
Bending Region Analysis