Methylmalonyl-Coa Mutase, Mitochondrial

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Methylmalonyl-Coa Mutase, Mitochondrial
  Conformer 1
(PDB) 		2xij (A)
  Conformer 2
(PDB) 		2xiq (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 281 0.63   39 - 111   262 - 299   307 - 391   395 - 464   469 - 471   484 - 495
2 240 1.31   115 - 261   300 - 306   465 - 468   472 - 474   478 - 483   510 - 512   518 - 576   585 - 591   625 - 628
3 181 1.15   392 - 394   475 - 477   496 - 509   513 - 517   577 - 584   592 - 624   629 - 743

Sequence


           ______________________________________________________________________108_______________________________________________ 
 2xij(A) : QQPLHPEWAALAKKQLKGKNPEDLIWHTPEGISIKPLYSKRDTMDLPEELPGVKPFTRGPYPTMYTFRPWTIRQYAGFSTVEESNKFYKDNIKAGQQGLSVAFDLATHRGYDSDNPRVRG 
         :                                                                                                                          
 2xiq(A) : QQPLHPEWAALAKKQLKGKNPEDLIWHTPEGISIKPLYSKRDTMDLPEELPGVKPFTRGPYPTMYTFRPWTIRQYAGFSTVEESNKFYKDNIKAGQQGLSVAFDLATHRGYDSDNPRVRG 
           ______________________________________________________________________108_______________________________________________ 

           _______________________________________________________________________________________________________261______________ 
 2xij(A) : DVGMAGVAIDTVEDTKILFDGIPLEKMSVSMTMNGAVIPVLANFIVTGEEQGVPKEKLTGTIQNDILKEFMVRNTYIFPPEPSMKIIADIFEYTAKHMPKFNSISISGYHMQEAGADAIL 
         :                                                                                                                          
 2xiq(A) : DVGMAGVAIDTVEDTKILFDGIPLEKMSVSMTMNGAVIPVLANFIVTGEEQGVPKEKLTGTIQNDILKEFMVRNTYIFPPEPSMKIIADIFEYTAKHMPKFNSISISGYHMQEAGADAIL 
           _______________________________________________________________________________________________________261______________ 

           _____________________299____306_________________________________________________________________________________390_____ 
 2xij(A) : ELAYTLADGLEYSRTGLQAGLTIDEFAPRLSFFWGIGMNFYMEIAKMRAGRRLWAHLIEKMFQPKNSKSLLLRAHCQTSGWSLTEQDPYNNIVRTAIEAMAAVFGGTQSLHTNSFDEALG 
         :                                                                                                                          
 2xiq(A) : ELAYTLADGLEYSRTGLQAGLTIDEFAPRLSFFWGIGMNFYMEIAKMRAGRRLWAHLIEKMFQPKNSKSLLLRAHCQTSGWSLTEQDPYNNIVRTAIEAMAAVFGGTQSLHTNSFDEALG 
           _____________________299____306_________________________________________________________________________________390_____ 

           __________________________________________________________________464_468___474_____482_________494____________509_____5 
 2xij(A) : LPTVKSARIARNTQIIIQEESGIPKVADPWGGSYMMECLTNDVYDAALKLINEIEEMGGMAKAVAEGIPKLRIEECAARRQARIDSGSEVIVGVNKYQLEKEDTVEVLAIDNTSVRNRQI 
         :                                                                                                                          
 2xiq(A) : LPTVKSARIARNTQIIIQEESGIPKVADPWGGSYMMECLTNDVYDAALKLINEIEEMGGMAKAVAEGIPKLRIEECAARRQARIDSGSEVIVGVNKYQLEKEDTVEVLAIDNTSVRNRQI 
           __________________________________________________________________464_468___474_____482_________494____________509_____5 

           17________________________________________________________576_____584____591______________________________624_628_______ 
 2xij(A) : EKLKKIKSSRDQALAERCLAALTECAASGDGNILALAVDASRARCTVGEITDALKKVFGEHKANDRMVSGAYRQEFGESKEITSAIKRVHKFMEREGRRPRLLVAKMGQDGHDRGAKVIA 
         :                                                                                                                          
 2xiq(A) : EKLKKIKSSRDQALAERCLAALTECAASGDGNILALAVDASRARCTVGEITDALKKVFGEHKANDRMVSGAYRQEFGESKEITSAIKRVHKFMEREGRRPRLLVAKMGQDGHDRGAKVIA 
           17________________________________________________________576_____584____591______________________________624_628_______ 

           __________________________________________________________________________________________________________________       
 2xij(A) : TGFADLGFDVDIGPLFQTPREVAQQAVDADVHAVGVSTLAAGHKTLVPELIKELNSLGRPDILVMCGGVIPPQDYEFLFEVGVSNVFGPGTRIPKAAVQVLDDIEKCLEK****       
         :                                                                                                                          
 2xiq(A) : TGFADLGFDVDIGPLFQTPREVAQQAVDADVHAVGVSTLAAGHKTLVPELIKELNSLGRPDILVMCGGVIPPQDYEFLFEVGVSNVFGPGTRIPKAAVQVLDDIEKCLEKKQQS       
           __________________________________________________________________________________________________________________       

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Domain Pairs

Fixed Domain Moving Domain Rotation Angle Translation   (A) Closure Bending Residues  
1 2 9.3 -0.8 98.6   108 - 134   261 - 262   299 - 300   306 - 307   464 - 465   468 - 469   471 - 472   482 - 485 Bending Region Analysis
1 3 11.2 0.1 96.6   390 - 399   494 - 508 Bending Region Analysis
3 2 8.9 0.2 91.6   474 - 475   477 - 478   509 - 510   512 - 513   517 - 523   576 - 577   584 - 585   591 - 593   624 - 625   628 - 629 Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 3 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 3

Movement classification: Hinge

PyMOL Script

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