DynDom - Protein Domain Motions

Mitogen-Activated Protein Kinase Fus3

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Mitogen-Activated Protein Kinase Fus3
Conformer 1 (PDB)	2b9h (A)
Conformer 2 (PDB)	2f49 (B)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	39	0.39	6 - 20 28 - 43 74 - 76 91 - 95
2	250	1.05	22 - 27 52 - 73 96 - 333
3	32	0.69	44 - 50 77 - 90 341 - 351

Sequence

`__________________20___25________________43_____50_____________________73_76____________90___95_________________________` `2b9h(A) : MPKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQ` `:` `2f49(B) : MPKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQ` `__________________20___25________________43_____50_____________________73_76____________90___95_________________________` `________________________________________________________________________________________________________________________` `2b9h(A) : TLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDvEFVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRA` `:` `2f49(B) : TLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDvEFVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRA` `________________________________________________________________________________________________________________________` `________________________________________________________________________331______________________` `2b9h(A) : REYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEIFS` `:` `2f49(B) : REYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEIFS` `________________________________________________________________________331______________________`

Morph

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Domain Pairs

Fixed Domain	Moving Domain	Rotation Angle	Translation (A)	Closure	Bending Residues
1	2	13.9	-0.3	99.7	20 - 22 25 - 28 73 - 74 95 - 96	Bending Region Analysis
1	3	13.8	0.4	87.1	43 - 44 76 - 77 90 - 91	Bending Region Analysis
3	2	12.2	-0.2	44.5	50 - 52 331 - 341	Bending Region Analysis