DynDom - Protein Domain Motions

Pentafunctional Arom Polypeptide

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Pentafunctional Arom Polypeptide
Conformer 1 (PDB)	6hqv (A)
Conformer 2 (PDB)	6hqv (B)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	147	0.6	868 - 1017 1020 - 1024 1028 - 1037 1041 - 1044
2	598	0.32	17 - 420 649 - 867
3	255	0.19	1018 - 1019 1025 - 1027 1038 - 1040 1045 - 1287 1289 - 1289 1312 - 1319 1569 - 1569
4	124	0.13	1288 - 1288 1290 - 1311 1320 - 1395 1551 - 1568 1570 - 1578
5	148	0.09	1396 - 1550
6	222	0.05	421 - 648

Sequence

`________________________________________________________________________________________________________________________` `6hqv(A) : EPTRIAILGKEDIIVDHGIWLNFVAHDLLQTLPSSTYVLITDTNLYTTYVPPFQAVFEAAAPRDVRLLTYAIPPGEYSKSRETKAEIEDWlSHACTRDTVIIALGGGVIGDiGYVAATFr` `:` `6hqv(B) : EPTRIAILGKEDIIVDHGIWLNFVAHDLLQTLPSSTYVLITDTNLYTTYVPPFQAVFEAAAPRDVRLLTYAIPPGEYSKSRETKAEIEDWlSHACTRDTVIIALGGGVIGDiGYVAATFr` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `6hqv(A) : GVRFVQVPTTLLAvDSSIGGKTAIDTPgKNLIGAFWQPRRIYIDLAFLETLPVREFINGaEVIKTAAIWNETEFTALEENAAAILEAVRSKASSPAARLAPIRHILKRIVLGSARVKAEV` `:` `6hqv(B) : GVRFVQVPTTLLAvDSSIGGKTAIDTPgKNLIGAFWQPRRIYIDLAFLETLPVREFINGaEVIKTAAIWNETEFTALEENAAAILEAVRSKASSPAARLAPIRHILKRIVLGSARVKAEV` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `6hqv(A) : VSADEREGGLRNLLNFGHSIGHAYEAILAPQVLHGECVAIGvKEAELARYLGVLRPSAVARLTKLIASYDLPTSVHDKRIAKLSAGKECPVDVLLQKaVDKKNEGRKKKIVLLSAIGKTY` `:` `6hqv(B) : VSADEREGGLRNLLNFGHSIGHAYEAILAPQVLHGECVAIGvKEAELARYLGVLRPSAVARLTKLIASYDLPTSVHDKRIAKLSAGKECPVDVLLQKaVDKKNEGRKKKIVLLSAIGKTY` `________________________________________________________________________________________________________________________` `______________________________415_______________________________________________________________________________________` `6hqv(A) : EKKATVVDDRAIRLVLSPSVRVTPGVPKGLSVTVTPPGSKSISNRALVLAALGEGTTRIHGLLHSDDVQYlAAIEQLHGADFSWEDAGEILVVTGKGGKLQASKEPLYLGNAGTASRFLT` `:` `6hqv(B) : EKKATVVDDRAIRLVLSPSVRVTPGVPKGLSVTVTPPGSKSISNRALVLAALGEGTTRIHGLLHSDDVQYlAAIEQLHGADFSWEDAGEILVVTGKGGKLQASKEPLYLGNAGTASRFLT` `______________________________415_______________________________________________________________________________________` `________________________________________________________________________________________________________________________` `6hqv(A) : SVVALCAPSAVSSTVLTGNARkVRPIGALVDALRANGVGVKYLEKEKSLPVEVDAAGGFAGGVIELAATVSSQYVSSILaAPYAHQPVTLRLVGGKPISQPYIDtIAaSFGIKVERSAED` `:` `6hqv(B) : SVVALCAPSAVSSTVLTGNARkVRPIGALVDALRANGVGVKYLEKEKSLPVEVDAAGGFAGGVIELAATVSSQYVSSILaAPYAHQPVTLRLVGGKPISQPYIDtIAaSFGIKVERSAED` `________________________________________________________________________________________________________________________` `________________647_____________________________________________________________________________________________________` `6hqv(A) : PNTYLIPKGVYKNPPEYVVESDASSATYPLAVAAITGTTCTIPNIGSESLQGDARFAVEVLRPgCAVEQTATSTTVTGPPIGTLKAIPHVDePtDAFLTAAVLAAVADGTTQITGIANQR` `:` `6hqv(B) : PNTYLIPKGVYKNPPEYVVESDASSATYPLAVAAITGTTCTIPNIGSESLQGDARFAVEVLRPgCAVEQTATSTTVTGPPIGTLKAIPHVDePtDAFLTAAVLAAVADGTTQITGIANQR` `________________647_____________________________________________________________________________________________________` `__________________________________________________________________________________________________866___________________` `6hqv(A) : VKECNRIAAkDQLAKFGVQCNELEDGIEVIGKPYQELRNPVEGIYCYDDHRVAsHSVLSTISPHPVLILERECTAKTWPGWWDILSQFFKVQLDGEEDPTgTDRSIFIVGrGAGKSTAGR` `:` `6hqv(B) : VKECNRIAAkDQLAKFGVQCNELEDGIEVIGKPYQELRNPVEGIYCYDDHRVAsHSVLSTISPHPVLILERECTAKTWPGWWDILSQFFKVQLDGEEDPTgTDRSIFIVGrGAGKSTAGR` `__________________________________________________________________________________________________866___________________` `________________________________________________________________________________________________________________________` `6hqv(A) : WsELLKRPLVDLDAELERREGtIPEIIRGERGWEGFRQAELELLQDVIKNQSKGYIFSCGGGIVETEAARKLLIDYHKNGGPVLLVHRDTDQVVEYLrDKTRPAYSENIREVYERRKPWF` `:` `6hqv(B) : WsELLKRPLVDLDAELERREGtIPEIIRGERGWEGFRQAELELLQDVIKNQSKGYIFSCGGGIVETEAARKLLIDYHKNGGPVLLVHRD------------------nIREVYERRKPWF` `________________________________________________________________________________________________________________________` `____1017___1024_________1037___1044_____________________________________________________________________________________` `6hqv(A) : YECSNLQYHSPHEDGSEALLQPPADFARFVKLIAGQSTHLEDVRAKKHSFFVSLTVPNVADALDIIPRVVVGSDAVELRVDLLESYEPEFVARQVALLRAAAQVPIVYTVRTQSQGGKFP` `:` `6hqv(B) : YECSNLQYHSPHEDGSEALLQPPADFARFVKLIAGQSTHLEDVRAKKHSFFVSLTVPNVADALDIIPRVVVGSDAVELRVDLLESYEPEFVARQVALLRAAAQVPIVYTVRTQSQGGKFP` `____1017___1024_________1037___1044_____________________________________________________________________________________` `________________________________________________________________________________________________________________________` `6hqv(A) : DEDYDLALRLYQTGLRSGVEYLDLEtpDHILQAVTDAKGFTSIIASHHDPQCKLSWKSGSWIPFYNKALQYGDVIKLVGVAREaDNFALTNFKAKlAAHDNKPiALNgTAGKLSRVLNGF` `:` `6hqv(B) : DEDYDLALRLYQTGLRSGVEYLDLEtpDHILQAVTDAKGFTSIIASHHDPQCKLSWKSGSWIPFYNKALQYGDVIKLVGVAREaDNFALTNFKAKlAAHDNKPiALNgTAGKLSRVLNGF` `________________________________________________________________________________________________________________________` `_________________________1284_______________________1311________________________________________________________________` `6hqv(A) : LTPVSHPALPSKAAPGQLSATEIRQALSLIGEIEPKSFYLFGKPISASRSPALHNTLFYKTGLPHHYSRFETDEASKALESLIRSPDFGGASVTIPLKLDIpLLDSATDAARTIGAVNTI` `:` `6hqv(B) : LTPVSHPALPSKAAPGQLSATEIRQALSLIGEIEPKSFYLFGKPISASRSPALHNTLFYKTGLPHHYSRFETDEASKALESLIRSPDFGGASVTIPLKLDIpLLDSATDAARTIGAVNTI` `_________________________1284_______________________1311________________________________________________________________` `_____________1393_______________________________________________________________________________________________________` `6hqv(A) : IPQTRDGSTTTLVGDNTDWRGvHALLHSSGSGSVVQRTAAPRGAAvVGSGGTARAAIYALHDLGFAPIWIVARSEERVAELVRGFDGYDLRRtSPHQGKDNpSVVISTIPATQPIDPSrE` `:` `6hqv(B) : IPQTRDGSTTTLVGDNTDWRGvHALLHSSGSGSVVQRTAAPRGAAvVGSGGTARAAIYALHDLGFAPIWIVARSEERVAELVRGFDGYDLRRtSPHQGKDNpSVVISTIPATQPIDPSrE` `_____________1393_______________________________________________________________________________________________________` `_____________________________________1544____________________1568____________` `6hqv(A) : VIVEVLKHGHPSAEGKVLLEaYQPPRTPLtLAEDQGWRTVGGLEVLAAQGWYQFQLWTGITPLYEEARAAVgEDSVE` `:` `6hqv(B) : VIVEVLKHGHPSAEGKVLLEaYQPPRTPLtLAEDQGWRTVGGLEVLAAQGWYQFQLWTGITPLYEEARAAVgEDSVE` `_____________________________________1544____________________1568____________`

Morph

Morph animation in progress.
Status: Initialising

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Fixed Domain	Moving Domain	Rotation Angle	Translation (A)	Closure	Bending Residues
1	2	8.1	-0.8	99.9	866 - 868	Bending Region Analysis
1	3	4.2	0.0	97.2	1017 - 1020 1024 - 1028 1037 - 1041 1044 - 1046	Bending Region Analysis
4	3	3.2	-0.1	16.2	1284 - 1291 1311 - 1320 1568 - 1570	Bending Region Analysis
4	5	8.8	0.1	98.3	1393 - 1399 1544 - 1552	Bending Region Analysis
2	6	3.2	-0.2	54.0	415 - 421 647 - 652	Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification:

No Contacts

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 4 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 4

Movement classification: Hinge

Conformer 1 Contact:
Residue 4 ———› Residue 5

Conformer 2 Contact:
Residue 5 ———› Residue 4

Movement classification:

No Contacts

Conformer 1 Contact:
Residue 2 ———› Residue 6

Conformer 2 Contact:
Residue 6 ———› Residue 2

Movement classification: Hinge

PyMOL Script

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