Potassium/sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 11

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Potassium/sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 11
  Conformer 1
(PDB) 		5u6o (A)
  Conformer 2
(PDB) 		3u10 (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 43 1.05   448 - 490
2 40 0.74   403 - 442
3 68 1.2   491 - 541   548 - 564
4 23 0.93   543 - 545   565 - 584

Sequence


           ________________________________________________________________________________________________________________________ 
 5u6o(A) : MQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVFLLDLIMNFRTGTVNsSEIILDPKVIKM 
         :                                                                                                                          
 3u10(A) : ************************************************************************************************************************ 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 5u6o(A) : NYLKSWFVVDFISSIPVDYIFLIVEKGrALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQ 
         :                                                                                                                          
 3u10(A) : ************************************************************************************************************************ 
           ________________________________________________________________________________________________________________________ 

           _______________________________________________________________________________________________442______________________ 
 5u6o(A) : YSYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILNELNDPLREEIVNF 
         :                                                                                                                          
 3u10(A) : ********************************************************DSSRRQYQEKYKQVEQYMSFHKLPADFRQKIHDYYEHRYQGKMFDEDSILGELNGPLREEIVNF 
           _______________________________________________________________________________________________511______________________ 

           _______________________490________________________________________________541_545________________564____________________ 
 5u6o(A) : NCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFE 
         :                                                                                                                          
 3u10(A) : NCRKLVASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKEMKLSDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFE 
           _______________________559________________________________________________610_614________________633____________________ 

           __________________                                                                                                       
 5u6o(A) : TV****************                                                                                                       
         :                                                                                                                          
 3u10(A) : TVAIDRLDRIGKKNSILL                                                                                                       
           __________________                                                                                                       

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Fixed Domain Moving Domain Rotation Angle Translation   (A) Closure Bending Residues  
1 2 8.5 -4.6 85.2   442 - 448 Bending Region Analysis
1 3 20.4 -0.4 44.5   490 - 491 Bending Region Analysis
3 4 24.8 0.5 98.3   541 - 543   545 - 550   564 - 565 Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification:

No Contacts

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 3 ———› Residue 4

Conformer 2 Contact:
Residue 4 ———› Residue 3

Movement classification:

No Contacts

PyMOL Script

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