Protein Phosphatase Pp2a

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Protein Phosphatase Pp2a
  Conformer 1
(PDB) 		1b3u (A)
  Conformer 2
(PDB) 		2nym (D)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 368 1.42   35 - 409
2 26 2.53   9 - 34
3 52 1.33   410 - 463
4 119 0.74   464 - 586

Sequence


           ________________________________34______________________________________________________________________________________ 
 1b3u(A) : AAADGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRSELLPFLTDTIYDEDEVLLALAEQLGTFTTLVGGPEYVHCLLPPLESLATVEETVVRDKAVESLRAISHEHSP 
         :                                                                                                                          
 2nym(D) : ******DSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRSELLPFLTDTIYDEDEVLLALAEQLGTFTTLVGGPEYVHCLLPPLESLATVEETVVRDKAVESLRAISHEHSP 
           ________________________________35______________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 1b3u(A) : SDLEAHFVPLVKRLAGGDWFTSRTSACGLFSVCYPRVSSAVKAELRQYFRNLCSDDTPMVRRAAASKLGEFAKVLELDNVKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLLPQEDLE 
         :                                                                                                                          
 2nym(D) : SDLEAHFVPLVKRLAGGDWFTSRTSACGLFSVCYPRVSSAVKAELRQYFRNLCSDDTP-vRRAAASKLGEFAKVLELDNVKSEIIP-fSNLASDEQDSVRLLAVEACVNIAQLLPQEDLE 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 1b3u(A) : ALVMPTLRQAAEDKSWRVRYMVADKFTELQKAVGPEITKTDLVPAFQNLMKDCEAEVRAAASHKVKEFCENLSADCRENVIMSQILPCIKELVSDANQHVKSALASVIMGLSPILGKDNT 
         :                                                                                                                          
 2nym(D) : ALV-pTLRQAAEDKSWRVRY-vADKFTELQKAVGPEITKTDLVPAFQNL-kDCEAEVRAAASHKVKEFCENLSADCRENVI-sQILPCIKELVSDANQHVKSALASVI-gLSPILGKDNT 
           ________________________________________________________________________________________________________________________ 

           _______________________________________402__________________________________________________________463_________________ 
 1b3u(A) : IEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATSNLKKLVEKFGKEWAHAT 
         :                                                                                                                          
 2nym(D) : IEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEY-pLLAGQLGVEFFDEKLNSLC-aWLVDHVYAIREAATSNLKKLVEKFGKEWAHAT 
           _______________________________________403__________________________________________________________464_________________ 

           ____________________________________________________________________________________________________________             
 1b3u(A) : IIPKVLAMSGDPNYLHRMTTLFCINVLSEVCGQDITTKHMLPTVLRMAGDPVANVRFNVAKSLQKIGPILDNSTLQSEVKPILEKLTQDQDVDVKYFAQEALTVLSLA             
         :                                                                                                                          
 2nym(D) : IIPKVLA-sGDPNYLHR-tTLFCINVLSEVCGQDITTKH-lPTVLR-aGDPVANVRFNVAKSLQKIGPILDNSTLQSEVKPILEKLTQDQDVDVKYFAQEALTVLSLA             
           ____________________________________________________________________________________________________________             

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Domain Pairs

Fixed Domain Moving Domain Rotation Angle Translation   (A) Closure Bending Residues  
1 2 46.4 0.4 10.7   34 - 35 Bending Region Analysis
1 3 33.0 3.2 74.8   402 - 410 Bending Region Analysis
4 3 27.9 -1.6 59.8   463 - 470 Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 4 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 4

Movement classification: Hinge

PyMOL Script

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