DynDom - Protein Domain Motions

Receptor Tyrosine-Protein Kinase Erbb-4

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Receptor Tyrosine-Protein Kinase Erbb-4
Conformer 1 (PDB)	2ahx (A)
Conformer 2 (PDB)	3u7u (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	277	2.22	3 - 237 258 - 306
2	20	1.13	238 - 257
3	248	1.05	307 - 554

Sequence

`________________________________________________________________________________________________________________________` `2ahx(A) : QSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTEILNG` `:` `3u7u(A) : QSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTEILNG` `________________________________________________________________________________________________________________________` `______________________________________________________________________________________________________________237_______` `2ahx(A) : GVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVSTgCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYN` `:` `3u7u(A) : GVYVDQNKFLCYADTIHWQDIVRNP--sNLTLVSsGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYN` `______________________________________________________________________________________________________________237_______` `__________257_________________________________________301_______________________________________________________________` `2ahx(A) : PTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCT-iCPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKL` `:` `3u7u(A) : PTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKL` `__________257_________________________________________301_______________________________________________________________` `________________________________________________________________________________________________________________________` `2ahx(A) : NVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSS` `:` `3u7u(A) : NVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSS` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `2ahx(A) : DGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENDSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQGCNGPT` `:` `3u7u(A) : DGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENDSICVECDPQCEKMEDGLLTCHGPGPDNCTKCS**********************************************` `________________________________________________________________________________________________________________________` `____________` `2ahx(A) : SHDCIYYPWTGH` `:` `3u7u(A) : **********` `____________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	46.2
Translation (A)	-0.9
Closure (%)	51.8
Bending Residues ( green )	237 - 239 257 - 263
Bending Region Analysis

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( yellow )	3
Rotation Angle (deg)	128.8
Translation (A)	3.6
Closure (%)	98.6
Bending Residues ( green )	301 - 308
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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